Sains Malaysiana 52(7)(2023): 2055-2067

http://doi.org/10.17576/jsm-2023-5207-13

Review on Food Insecurity and Its Relationship with Iron and Vitamin B₁₂ Status among Children

 (Tinjauan Ketidakjaminan Makanan serta Hubungannya dengan Status Ferum dan Vitamin B₁₂ dalam Kalangan Kanak-Kanak)

WAN SITI FATIMAH WAN ABDUL RAHMAN¹, SITI BALKIS BUDIN^1,*, TANG SWEE FONG² & POH BEE KOON¹

¹Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

²Paediatric Intensive Care Unit (PICU), UKM Specialist Children's Hospital, Jalan Yaacob Latif, Bandar Tun Razak Cheras, 56000 Kuala Lumpur, Malaysia

Diserahkan: 25 November 2022/Diterima: 10 Julai 2023

Abstract

Iron and vitamin B₁₂ are essential micronutrients needed for the growth and development of children. Iron is critical for erythropoiesis, notably in haemoglobin synthesis whereby haemoglobin transports oxygen to cells, which is essential for cellular metabolism and energy production. Meanwhile, vitamin B₁₂ is required for deoxyribonucleic acid synthesis, intracellular metabolism, and blood cells formation and maturation. Lack of these essential micronutrients can lead to nutritional deficiency and anaemia, especially among children. Food insecurity is a condition where there is a lack of or uncertain availability of acquiring acceptable food. Food insecurity is associated with lower nutrient intake and micronutrient deficiencies including iron and vitamin B₁₂, which can subsequently lead to poor health outcomes. Various determinants are associated with iron and vitamin B₁₂ deficiency, and food insecurity, such as socio-economic factors, environmental factors, and dietary intake. This review will explore the possible relationship between iron, vitamin B₁₂, and anaemia with food insecurity among children. 

Keywords: Anaemia; dietary intake; food insecurity; micronutrients; socio-economic factors

Abstrak

Ferum dan vitamin B₁₂ adalah mikronutrien penting yang diperlukan bagi tumbesaran dan perkembangan kanak-kanak. Ferum penting untuk eritropoiesis, terutamanya dalam penghasilan hemoglobin kerana hemoglobin berperanan untuk mengangkut oksigen ke sel-sel dan ini penting bagi metabolisme sel dan penghasilan tenaga. Di samping itu, vitamin B₁₂ diperlukan untuk sintesis asid deoksiribonukleik, metabolisme intrasel, serta pembentukan dan pematangan sel darah. Kekurangan mikronutrien penting ini boleh membawa kepada kurang pemakanan dan anemia terutamanya dalam kalangan kanak-kanak. Ketidakjaminan makanan adalah keadaan terdapat kekurangan atau ketersediaan yang tidak pasti untuk memperoleh makanan yang boleh diterima. Ketidakjaminan makanan dikaitkan dengan kekurangan pengambilan nutrien dan kekurangan mikronutrien termasuklah ferum dan vitamin B₁₂ yang seterusnya menyebabkan kesan yang berpanjangan kepada kesihatan. Pelbagai faktor penentu yang dikaitkan dengan kekurangan ferum dan vitamin B₁₂, serta ketidakjaminan makanan seperti status sosioekonomi, faktor persekitaran dan pengambilan makanan. Oleh itu, tinjauan ini bertujuan meneroka hubungan ferum, vitamin B₁₂, dan anemia dengan ketidakjaminan makanan dalam kalangan kanak-kanak.

Kata kunci: Anemia; faktor sosioekonomi; ketidakjaminan makanan; mikronutrien; pengambilan makanan

RUJUKAN

Ankar, A. & Kumar, A. 2021. Vitamin B12 deficiency. StatPearls [Internet]. StatPearls Publishing.

Aquino, J.D.S., Sequeira-de-Andrade, L.A.S., Silva, P.E.B.A.D., Silva, A.P.D., Vieira, C.R.D.S. & Lira, P.I.C.D. 2014. Food insecurity and socioeconomic, food and nutrition profile of schoolchildren living in urban and rural areas of Picos, Piauí. Revista de Nutrição 27: 395-404.

Ballard, T.J., Kepple, A.W. & Cafiero, C. 2013. The food insecurity experience scale: Development of a global standard for monitoring hunger worldwide. Rome: Food and Agriculture Organization of the United Nations. http://www.fao.org/economic/ess/ess-fs/voices/en/

Bayoumi, I., Parkin, P.C., Birken, C.S., Maguire, J.L., Borkhoff, C.M. & TARGet Kids! Collaboration. 2020. Association of family income and risk of food insecurity with iron status in young children. JAMA Network Open 3(7): e208603-e208603.

Belachew, T., Lindstrom, D., Gebremariam, A., Hogan, D., Lachat, C., Huybregts, L. & Kolsteren, P. 2013. Food insecurity, food based coping strategies and suboptimal dietary practices of adolescents in Jimma zone Southwest Ethiopia. PloS ONE 8(3): e57643.

Bernal, J., Frongillo, E.A. & Rivera, J.A. 2016. Food insecurity reported by children, but not by mothers, is associated with lower quality of diet and shifts in foods consumed. Maternal & Child Nutrition 12(3): 546-557.

Bernal, J., Frongillo, E.A., Herrera, H.A. & Rivera, J.A. 2014. Food insecurity in children but not in their mothers is associated with altered activities, school absenteeism, and stunting. Journal of Nutrition 144: 1619-1626.

Bhattacharya, P.T., Misra, S.R. & Hussain, M. 2016. Nutritional aspects of essential trace elements in oral health and disease: An extensive review. Scientifica (Cairo) 2016: 5464373.

Bickel, G., Nord, M., Price, C., Hamilton, W. & Cook, J. 2000. Guide to Measuring Household Food Security, Revised 2000. U.S. Department of Agriculture, Food and Nutrition Service, Alexandria V.A.

Brotanek, J.M., Gosz, J., Weitzman, M. & Flores, G. 2008. Secular trends in the prevalence of iron deficiency among US toddlers, 1976-2002. Arch. Pediatr. Adolesc. Med. 162(4): 374-381.

Brouwer-Brolsma, E.M., Dhonukshe-Rutten, R.A., Van Wijngaarden, J.P., Zwaluw, N.L., Velde, N.V.D. & De Groot, L.C. 2015. Dietary sources of vitamin B-12 and their association with vitamin B-12 status markers in healthy older adults in the B-PROOF study. Nutrients 7(9): 7781-7797.

Camaschella, C. 2019. Iron deficiency. Blood. 133(1): 30-39.

Centre for Disease Control and Prevention (CDC). 2021. Child Development: Positive Parenting Tips.https://www.cdc.gov/ncbddd/childdevelopment/positiveparenting/index.html. Accessed on 7 January 2022.

Charles Shapu, R., Ismail, S., Ahmad, N., Lim, P.Y. & Abubakar Njodi, I. 2020. Food security and hygiene practice among adolescent girls in Maiduguri metropolitan council, Borno state, Nigeria. Foods 9(9): 1265.

Choi, H.J., Lee, H.J., Jang, H.B., Park, J.Y., Kang, J.H., Park, K.H. & Song, J. 2011. Effects of maternal education on diet, anemia, and iron deficiency in Korean school-aged children. BMC Public Health 11(1): 1-8.

Chowdhury, M.R.K., Khan, M.M.H., Rafiqul Islam, M., Perera, N.K., Shumack, M.K. & Kader, M. 2016. Low maternal education and socio‐economic status were associated with household food insecurity in children under five with diarrhoea in Bangladesh. Acta Paediatrica 105(5): 555-561.

Christian, A.M., Krishnaveni, G.V., Kehoe, S.H., Veena, S.R., Khanum, R., Marley-Zagar, E., Edwards, P., Margetts, B.M. & Fall, C.H. 2015. Contribution of food sources to the vitamin B12 status of South Indian children from a birth cohort recruited in the city of Mysore. Public Health Nutrition 18(4): 596-609.

Coates, J., Swindale, A. & Bilinsky, P. 2007. Household Food Insecurity Access Scale (HFIAS) for Measurement of Food Access: Indicator Guide V3 Food and Nutrition Technical Assistance Project (FANTA). Washington, DC.

Cobayashi, F., Tomita, L.Y., Augusto, R.A., D’Almeida, V. & Cardoso, M.A. 2015. Genetic and environmental factors associated with vitamin B12 status in Amazonian children. Public Health Nutrition 18(12): 2202-2210.

Cutler-Triggs, C., Fryer, G.E., Miyoshi, T.J. & Weitzman, M. 2008. Increased rates and severity of child and adult food insecurity in households with adult smokers. Archives of Pediatrics & Adolescent Medicine 162(11): 1056-1062.

Dagnelie, P.C., van Staveren, W.A., Vergote, F.J., Dingjan, P.G., van den Berg H. & Hautvast J.G. 1989. Increased risk of vitamin B12 and iron deficiency in infants on macrobiotic diets. Am. J. Clin. Nutr. 50: 818-824.

Das, J.K., Salam, R.A., Thornburg, K.L., Prentice, A.M., Campisi, S., Lassi, Z.S., Koletzko, B. & Bhutta, Z.A. 2017. Nutrition in adolescents: Physiology, metabolism, and nutritional needs. Ann. N. Y. Acad. Sci. 1393(1): 21-33.

dela Luna, K.L.G. & Bullecer, E.R. 2020. Rural and urban differences in household food insecurity and diet diversity of preschool children (PSC) in occidental Mindoro. Acta Medica Philippina 54: 5.

Devalia, V., Hamilton, M.S. & Molloy, A.M. 2014. British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br. J. Haematol. 166(4): 496-513.

Eicher-Miller, H.A., Mason, A.C., Weaver, C.M., McCabe, G.P. & Boushey, C.J. 2009. Food insecurity is associated with iron deficiency anemia in US adolescents. The American Journal of Clinical Nutrition 90(5): 1358-1371.

FAO. 2006. Rome Declaration on World Food Security and World Food Summit Plan of Action. World Food Summit 13-17 November 1996. Rome. http://www.fao.org/fileadmin/templates/faoitaly/documents/pdf/pdf_Food_Security_Cocept_Note.pdf

Fram, M.S., Frongillo, E.A., Draper, C.L. & Fishbein, E.M. 2013. Development and validation of a child report assessment of child food insecurity and comparison to parent report assessment. J. Hunger Environ. Nutr. 8: 128-145.

Fram, M.S., Bernal, J. & Frongillo, E.A. 2015. The Measurement of Food Insecurity among Children: Review of Literature and Concept Note, Innocenti Working Paper No. 2015-08, UNICEF Office of Research, Florence.

Garriguet, D. 2009. Diet quality in Canada. Health Reports 20(3): 41.

Gompakis, N., Economou, M., Tsantali, C., Kouloulias, V., Keramida, M. & Athanasiou-Metaxa, M. 2007. The effect of dietary habits and socioeconomic status on the prevalence of iron deficiency in children of northern Greece. Acta Haematol. 117(4): 200-204.

Green, R. 2017. Vitamin B₁₂ deficiency from the perspective of a practicing hematologist. Blood 129(19): 2603-2611.

Guo, B. 2011. Household assets and food security: Evidence from the survey of program dynamics. J. Fam. Econ. Iss. 32: 98-110.

Hanson, K.L. & Connor, L.M. 2014. Food insecurity and dietary quality in US adults and children: A systematic review. The American Journal of Clinical Nutrition 100(2): 684-692.

Jyoti, D.F., Frongillo, E.A. & Jones, S.J. 2005. Food insecurity affects school children's academic performance, weight gain, and social skills. The Journal of nutrition 135(12): 2831-2839.

Kirkpatrick, S.I. & Tarasuk, V. 2008. Food insecurity is associated with nutrient inadequacies among Canadian adults and adolescents. The Journal of Nutrition 138(3): 604-612.

Kreusler, P., Vogel, M., Willenberg, A., Baber, R., Dietz, Y., Körner, A., Ceglarek, U. & Kiess, W. 2021. Folate and cobalamin serum levels in healthy children and adolescents and their association with age, sex, BMI and socioeconomic status. Nutrients 13(2): 546.

Le Nguyen, B.K., Le Thi, H., Thuy, N.T., Huu, C.N., Do, T.T., Deurenberg, P. & Khouw, I. 2013. Double burden of undernutrition and overnutrition in Vietnam in 2011: Results of the SEANUTS study in 0·5–11-year-old children. British Journal of Nutrition 110(S3): S45-S56.

Maguire, J.L., Salehi, L., Birken, C.S., Carsley, S., Mamdani, M., Thorpe, K.E., Lebovic, G., Khovratovich, M., Parkin, P.C. & TARGet Kids! Collaboration. 2013. Association between total duration of breastfeeding and iron deficiency. Pediatrics 131(5): e1530-1537.

Mahajan, G., Sikka, M., Rusia, U. & Bhatia, M.S. 2011. Iron profile in children with behavioural disorders: A prospective study in a tertiary care hospital in north India. Indian Journal Hematology Blood Transfusion 27(2): 75-80.

McGuire, S. 2015. FAO, IFAD and WFP. The State of Food Insecurity in the World 2015. Meeting the 2015 International Hunger Targets: Taking Stock of Uneven Progress. Rome: FAO.

Melchior, M., Chastang, J.F., Falissard, B., Galera, C., Tremblay, R.E., Côté, S.M. & Boivin, M. 2012. Food insecurity and children’s mental health: A prospective birth cohort study. PLoS ONE 7(12): e52615.

Metallinos-Katsaras, E., Colchamiro, R., Edelstein, S. & Siu, E. 2016. Household food security status is associated with anemia risk at age 18 months among low-income infants in Massachusetts. Journal of the Academy of Nutrition and Dietetics 116(11): 1760-1766.

Miniero, R., Talarico, V., Galati, M.C., Laura Giancotti, L., Saracco, P. & Raiola, G. 2018. Iron deficiency and iron deficiency anemia in children, In Iron Deficiency Anemia, edited by Rodrigo, L. IntechOpen.

Morales, M.E. & Berkowitz, S.A. 2016. The relationship between food insecurity, dietary patterns, and obesity. Current Nutrition Reports 5(1): 54-60.

Ngui, R., Ishak, S., Chuen, C.S., Mahmud, R. & Lim, Y.A. 2011. Prevalence and risk factors of intestinal parasitism in rural and remote West Malaysia. PLoS Neglected Tropical Diseases 5(3): e974.

Nik Shanita, S., Siti Hanisa, A., Noor Afifah, A.R., Lee, S.T., Chong, K.H., George, P., Norazida, A.B., Budin, S.B., Khouw, I., Norimah, A.K. & Poh, B.K. 2018. Prevalence of anaemia and iron deficiency among primary schoolchildren in Malaysia. International Journal of Environmental Research and Public Health 15(11): 2332.

Olayemi, A.O. 2012. Effects of family size on household food security in Osun State, Nigeria. Asian Journal of Agriculture and Rural Development 2(393-2016-23999): 136-141.

Parkin, P.C. & Maguire, J.L. 2013. Iron deficiency in early childhood. CMAJ 185(14): 1237-1238.

Pasricha, S.R., Shet, A.S., Black, J.F., Sudarshan, H., Prashanth, N.S. & Biggs, B.A. 2011. Vitamin B-12, folate, iron, and vitamin A concentrations in rural Indian children are associated with continued breastfeeding, complementary diet, and maternal nutrition. The American Journal of Clinical Nutrition 94(5): 1358-1370.

Pawlak, R., Vos, P., Shahab-Ferdows, S., Hampel, D., Allen, L.H., & Perrin, M.T. 2018. Vitamin B-12 content in breast milk of vegan, vegetarian, and nonvegetarian lactating women in the United States. The American journal of clinical nutrition 108(3):525-531.

Pereira, A., Handa, S. & Holmqvist, G. 2021. Estimating the prevalence of food insecurity of households with children under 15 years, across the globe. Global Food Security 28: 100482.

Pérez-Escamilla, R., Parás, P., Acosta, M.J., Peyrou, S., Nord, M. & Hromi-Fiedler, A. 2011. Are the Latin American and Caribbean Food Security Scale (ELCSA) items comparable across countries? FASEB J. 25: 226-228.

Pirkle, C.M., Lucas, M., Dallaire, R., Ayotte, P., Jacobson, J.L., Jacobson, S.W., Dewailly, E. & Muckle, G. 2014. Food insecurity and nutritional biomarkers in relation to stature in Inuit children from Nunavik. Canadian Journal of Public Health 105(4): e233-e238.

Radimer, K.L., Olson, C.M. & Campbell, C.C. 1990. Development of indicators to assess hunger. J. Nutr. 120(11 Suppl): 1544-1548.

Roganović, J. & Starinac, K. 2018. Iron deficiency anemia in children. In Current Topics in Anemia, edited by Khan, J. IntechOpen.

Rojroongwasinkul, N., Kijboonchoo, K., Wimonpeerapattana, W., Purttiponthanee, S., Yamborisut, U., Boonpraderm, A., Kunapan, P., Thasanasuwan, W. & Khouw, I. 2013. SEANUTS: The nutritional status and dietary intakes of 0.5-12-year-old Thai children. British Journal of Nutrition 110(S3): S36-44.

Saaka, M. & Osman, S.M. 2013. Does household food insecurity affect the nutritional status of preschool children aged 6-36 months? International Journal of Population Research 2013: Article ID. 304169.

Saha, K.K., Tofail, F., Frongillo, E.A., Rasmussen, K.M., Arifeen, S.E., Persson, L.Å., Huda, S.N. & Hamadani, J.D. 2010. Household food security is associated with early childhood language development: Results from a longitudinal study in rural Bangladesh. Child: Care, Health and Development 36(3): 309-316.

Sandjaja, S., Budiman, B., Harahap, H., Ernawati, F., Soekatri, M., Widodo, Y. & Khouw, I. 2013. Food consumption and nutritional and biochemical status of 0·5–12-year-old Indonesian children: The SEANUTS study. British Journal of Nutrition 110(S3): S11-S20.

Sekhar, D.L., Murray-Kolb, L.E., Kunselman, A.R. & Paul, I.M. 2015. Identifying factors predicting iron deficiency in United States adolescent females using the ferritin and the body iron models. Clinical Nutrition ESPEN 10(3): e118–e123.

Sellen, D.W., Tedstone, A.E. & Frize, J. 2002. Food insecurity among refugee families in East London: Results of a pilot assessment. Public Health Nutr. 5(5): 637-644.

Shahab-Ferdows, S., Engle-Stone, R., Hampel, D., Ndjebayi, A.O., Nankap, M., Brown, K.H. & Allen L.H. 2015. Regional, socioeconomic, and dietary risk factors for vitamin B-12 deficiency differ from those for folate deficiency in Cameroonian women and children. J. Nutr. 145(11): 2587-2595.

Sharif, Z.M. & Ang, M. 2001. Assessment of food insecurity among low income households in Kuala Lumpur using the Radimer/Cornell food insecurity instrument - A validation study. Malaysian Journal of Nutrition 7(1 & 2): 15-32.

Sheng, X., Wang, J., Li, F., Ouyang, F. & Ma, J. 2019. Effects of dietary intervention on vitamin B12 status and cognitive level of 18-month-old toddlers in high-poverty areas: A cluster-randomized controlled trial. BMC Pediatrics 19(1): 1-9.

Skalicky, A., Meyers, A.F., Adams, W.G., Yang, Z., Cook, J.T. & Frank, D.A. 2006. Child food insecurity and iron deficiency anemia in low-income infants and toddlers in the United States. Matern. Child Health. J. 10(2): 177-185.

Smith, A.D., Warren, M.J. & Refsum, H. 2018. Vitamin B₁₂. Adv. Food Nutr. Res. 83: 215-279.

Sulaiman, N., Yeatman, H., Russell, J. & Law, L.S. 2021. A food insecurity systematic review: Experience from Malaysia. Nutrients 13(3): 945.

Uijterschout, L., Vloemans, J., Vos, R., Teunisse, P.P., Hudig, C., Bubbers, S., Verbruggen, S., Veldhorst, M., de Leeuw, T., van Goudoever, J.B. & Brus, F. 2014. Prevalence and risk factors of iron deficiency in healthy young children in the southwestern Netherlands. Journal of Pediatric Gastroenterology and Nutrition 58(2): 193-198.

United Nation Convention. 1989.  The United Nations Convention on the Rights of the Child. https://www.unicef.org/media/60981/file/convention-rights-child-text-child-friendly-version.pdf

United States Department of Agriculture Economic Research Service. 2014. Food Security in the US: Measurement.  http://www.ers.usda.gov/topics/food-nutrition-assistance/food-security-in-the-us/measurement.aspx#.U5nWcoWJuDk

Villamor, E., Mora-Plazas, M., Forero, Y., Lopez-Arana, S. & Baylin, A. 2008. Vitamin B-12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children. J. Nutr. 138(7): 1391-1398.

Vázquez-López, M.A., López-Ruzafa, E., Ibáñez-Alcalde, M., Martín-González, M., Bonillo-Perales, A. & Lendínez-Molinos, F. 2019. The usefulness of reticulocyte haemoglobin content, serum transferrin receptor and the sTfR-ferritin index to identify iron deficiency in healthy children aged 1-16 years. Eur. J. Pediat. 178(1): 41-49.

World Health Organization (WHO). ‎2020‎. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. World Health Organization. https://apps.who.int/iris/handle/10665/331505

World Health Organization (WHO). 2014. Serum transferrin receptor levels for the assessment of iron status and iron deficiency in populations. Vitamin and Mineral Nutrition Information System (WHO/NMH/NHD/MNM/14.6). Geneva, Switzerland. https://apps.who.int/iris/bitstream/handle/10665/133707/WHO_NMH_NHD_EPG_14.6_eng.pdf?sequence=1&isAllowed=y

World Health Organization (WHO). 2011. Intermittent Iron Supplementation in Preschool and School-Age Children. WHO: Geneva, Switzerland.

Yen, C.E., Yen, C.H., Cheng, C.H. & Huang, Y.C. 2010. Vitamin B-12 status is not associated with plasma homocysteine in parents and their preschool children: lacto-ovo, lacto, and ovo vegetarians and omnivores. Journal of the American College of Nutrition 29(1): 7-13.

*Pengarang untuk surat-menyurat, email: balkis@ukm.edu.my